Force Display in Molecular Docking

Acknowledgement I would like to thank my thesis advisor, Professor Frederick P. Brooks, Jr., for his full support of the ARM project. In 1976 he already had the idea to the use force-feedback ARM in the molecular docking problems. Dr. Mike Cory and Professor David Richardson were the pioneer users of the prototype system from the beginning. have given useful suggestions in my experimental design. The ARM project is a team work, many people contributed to the development of the ARM system. Michael Pique, former GRIP director, laid out all the necessary components of the ARM system, even before I joined the GRIP project. Successive GRIP director Helga Thorvaldsdottir and GRIP chemist Mark Harris helped me with software and chemical problems. John Hughes has been in the ARM team since the beginning of the project; he bnilt most of the hardware components, and maintained them. Neela Srinivasan wrote the PS300 interface, and the second version of the energy evaluator. Ji-Fang Wang helped me to establish the link to Pixel-planes-4 graphics engine. Lee Kuyper and Dr. Mike Cory furnished the molecular data. There were twelve biochemists participating in my molecular docking experiments. They had provided useful advices in improving the system design. They are